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With the concept that a more rapid cell cycle can be a key part of pluripotency, reprogramming effectiveness may be improved. Solutions for enhancing pluripotency by way of manipulation of cell cycle regulators contain: overexpression of Cyclin D/Cdk4, phosphorylation of Sox2 at S39 and S253, overexpression of Cyclin A and Cyclin E, knockdown of Rb

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